Joanna The_mad (Juana) …, daughter of Ferdinand_v … and Isabella …, was born in 1479 and died in 1555 at the age of 76. She married Philip_i The_handsome … in 1496. He was born in 1478 in Bruges, Flanders and died in 1506 at the age of 28.

Eleanor …, daughter of Philip_i The_handsome … and Joanna The_mad (Juana) …, was born in 1498 and died in 1558 at the age of 60. She married 2 times. The first time she married Emanuel … in 1519. He was born in 1469 and died in 1521 at the age of 52. The second time she married Francis_i …, son of Charles Of_valois … and Louise Of_savoy …, on July 8, 1530. He was born on September 12, 1494 in Cognac, France and died on March 31, 1547 in Rambouillet, France at the age of 52.

Charles_v …, son of Philip_i The_handsome … and Joanna The_mad (Juana) …, was born in 1500 and died in 1558 at the age of 58. He married Isabella Of_portugal …. She was born in 1503 and died in 1539 at the age of 36.

Philip_ii …, son of Charles_v … and Isabella Of_portugal …, was born on May 21, 1527 in Valladolid and died on September 13, 1598 in El Escorial, Palace, Madrid, Spain at the age of 71. He married 4 times. The first time he married Maria Of_portugal … in 1543. The second time he married Mary_i Tudor, daughter of Henry_viii Tudor and Catherine Of_aragon …, on July 25, 1554 in Winchester, Cathedral, , England. She was born on February 18, 1516 in Greenwich Palace, London, England and died on November 17, 1558 in St. James Palace, , England at the age of 42. The third time he married Elizabeth Of_france …. She was born in 1545 and died in 1568 at the age of 23. The fourth time he married Anne Of_austria … in 1570. She was born in 1549 and died in 1580 at the age of 31.