Isabella Of_portugal … was born in 1503 and died in 1539 at the age of 36. She married Charles_v …, son of Philip_i The_handsome … and Joanna The_mad (Juana) …,. He was born in 1500 and died in 1558 at the age of 58.

Philip_ii …, son of Charles_v … and Isabella Of_portugal …, was born on May 21, 1527 in Valladolid and died on September 13, 1598 in El Escorial, Palace, Madrid, Spain at the age of 71. He married 4 times. The first time he married Maria Of_portugal … in 1543. The second time he married Mary_i Tudor, daughter of Henry_viii Tudor and Catherine Of_aragon …, on July 25, 1554 in Winchester, Cathedral, , England. She was born on February 18, 1516 in Greenwich Palace, London, England and died on November 17, 1558 in St. James Palace, , England at the age of 42. The third time he married Elizabeth Of_france …. She was born in 1545 and died in 1568 at the age of 23. The fourth time he married Anne Of_austria … in 1570. She was born in 1549 and died in 1580 at the age of 31.

Philip_iii …, son of Philip_ii … and Anne Of_austria …, was born in 1578 in Madrid, , , Spain and died in 1621 at the age of 43. He married Margaret Of_austria …, daughter of Charles …, in 1599. She was born in 1584 and died in 1611 at the age of 27.